Name | Triprolidine hydrochloride |
Synonyms | Venen Triprolidine hcl TRIPROLIDINE HCL Triprolidine hydrochloride TRANS-TRIPROLIDINE HYDROCHLORIDE triprolidine hydrochloride (anh.) (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride TRANS-2[3-(1-PYRROLIDINYL)-1-P-TOLYLPROPENYL]PYRIDINE HYDROCHLORIDE 2-[(1E)-1-(4-Methylphenyl)-3-pyrrolizino-1-propenyl]pyridine·hydrochloride (E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride 2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine monohydrochloride (E)-2-[1-(4-METHYLPHENYL)-3-(1-PYRROLIDINYL)-1-PROPENYL]PYRIDINE HYDROCHLORIDE |
CAS | 550-70-9 |
EINECS | 208-985-0 |
InChI | InChI=1/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+ |
Molecular Formula | C19H23ClN2 |
Molar Mass | 314.85 |
Melting Point | 116-118 °C |
Storage Condition | 2-8°C |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | 3249 |
WGK Germany | 3 |
RTECS | UT7658000 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 oral in rat: 840mg/kg |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
biological activity | Triprolidine hydrochloride belongs to the first generation of antihistamines and is a histamine H1 (histamine H1) antagonist with oral activity, which can be used for the study of allergic rhinitis. In rats, Triprolidine hydrochloride can block spinal cord movement and perception. |
Animal Model: | Male Sprague-Dawley rat (300-350 g) |
Dosage: | 292.81 μg/kg, 488.02 μg/kg, 733.60μg/kg, 1098.83 μg/kg, 1467.20 μg/kg |
Administration: | Intrathecal injection |
Result: | Elicited a dose-dependent spinal block. |